Publications

Dernière publication 30/07/2010

Analgesic properties of calcium phosphate apatite loaded with bupivacaine on pos

Synthetic calcium-deficient apatites (CDA) are structurally similar to biological apatites and are well known as chemical precursors of biphasic...

Array
(
    [id_prestablog_news] => 263
    [id_shop] => 1
    [date] => 2010-07-30 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 524
    [id_lang] => 2
    [title] => Analgesic properties of calcium phosphate apatite loaded with bupivacaine on pos
    [paragraph] => Analgesic properties of calcium phosphate apatite loaded with bupivacaine on postoperative pain. 
    [content] => 
Authors
E. Verron, O. Gauthier, P. Janvier, H. Le Guen, D. Holopherne et al. 

 Lab
Nantes Atlantique Universités, INSERM UMR 791, Nantes, France.
Journal
Journal of Biomedical Materials Research
Abstract
Synthetic calcium-deficient apatites (CDA) are structurally similar to biological apatites and are well known as chemical precursors of biphasic calcium phosphates (BCP). BCP are mixtures of hydroxyapatite and beta-tricalcium phosphate and are widely used as bone substitutes in human surgery. Bupivacaine, a local anesthetic, has been loaded onto CDA using isostatic compaction. The purpose of this study was to evaluate the in vivo performance of such a local release on pain after having previously defined the in vitro release profile of bupivacaine. CDA was loaded with 1%, 4%, and 16% of bupivacaine using an isostatic compaction process. In vitro release profile assays performed indicated the complete release of bupivacaine after 24 h. Wistar male rats received 50 mg implants of CDA associated, respectively, with 0, 1%, 4%, and 16% of bupivacaine into the distal femur. Analgesia was measured using the electronic version of the Von Frey monofilament test, assessing the inflammatory response and a neurological score. During the first postoperative days, a dose-dependent analgesic effect was observed with the bupivacaine adsorbed on the resorbable implant. This combined device system thus appears to release local anesthetic in a manner that prevents or limits postoperative pain following bone surgery. This innovative approach could be integrated into a global pain management program, for example, in the context of bone harvesting where bone reconstruction is required.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
    [meta_description] => 
    [meta_keywords] => http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31628/abstract
    [meta_title] => 
    [link_rewrite] => analgesic-properties-of-calcium-phosphate-apatite-loaded-with-bupivacaine-on-postoperative-pain--
    [actif_langue] => 1
    [read] => 1082
    [count_comments] => 0
    [id] => 263
    [categories] => Array
        (
            [10] => Array
                (
                    [id_prestablog_categorie] => 10
                    [title] => Douleur
                    [link_rewrite] => Douleur
                )

            [33] => Array
                (
                    [id_prestablog_categorie] => 33
                    [title] => Douleurs post-opératoires
                    [link_rewrite] => Douleurs-post-opératoires
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Analgesic properties of calcium phosphate apatite loaded with bupivacaine on postoperative pain. 
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1859] => Array
                (
                    [name] => Von Frey Électronique - Sans Fil
                    [description_short] => 
Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1859-electronic-von-frey-4.html
                )

            [1860] => Array
                (
                    [name] => Von Frey Électronique 5 avec caméra intégrée
                    [description_short] => 

En tant que version électronique du classique esthésiomètre à filaments de Von Frey, la dernière évolution de l’instrument électronique Von Frey de Bioseb, conçu pour déterminer le seuil de sensibilité mécanique chez les rongeurs (rats et souris) par stimulation sous la patte, est un outil indispensable pour vos recherches sur l’hyperalgésie et l’allodynie. En mesurant et en enregistrant la force à laquelle l’animal présente un réflexe de retrait de la patte, il est possible d’étudier les pathologies liées à la réponse sensorielle ainsi qu’à l’hyper- ou l’hypoesthésie.
L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1860-electronic-von-frey-5-with-embedded-camera.html
                )

        )

)
1