Publications

Dernière publication 01/05/2022

Comprehensive Evaluation of Long-term Dynamic Mechanical Behavior in a Rat MIA O

Osteoarthritis (OA) is highly prevalent across the world with 30% of the US population who are 45 and older estimated to have knee osteoarthritis....

Array
(
    [id_prestablog_news] => 1558
    [id_shop] => 1
    [date] => 2022-05-01 00:00:00
    [date_modification] => 2024-02-09 14:15:13
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 3323
    [id_lang] => 2
    [title] => Comprehensive Evaluation of Long-term Dynamic Mechanical Behavior in a Rat MIA O
    [paragraph] => Comprehensive Evaluation of Long-term Dynamic Mechanical Behavior in a Rat MIA OA Model
    [content] => 
Authors
D Kishnan, E Orozco, L Nair 

 Lab
Department of Biomedical Engineering, University of Connecticut, USA
Journal
The Journal of Pain
Abstract
Osteoarthritis (OA) is highly prevalent across the world with 30% of the US population who are 45 and older estimated to have knee osteoarthritis. The primary clinical indication of OA is pain. Mono-iodo acetate (MIA) induced osteoarthritis is commonly used to study pain in pre-clinical models. Currently mechanical allodynia and thermal hyperalgesia are used to measure the pain outcomes in most pre-clinical models however, the non-evoked dynamic weight bearing analysis provides more clinically relevant behavioral assessment of pain. The goal of the study is to comprehensively understand the changes in dynamic weight bearing behavior of rats with MIA induced OA over a period of 16 weeks. Osteoarthritis was induced in female Sprague-Dawley rats by C-arm guided injections of MIA (3 mg) into the intra-articular region of the right knee. Non-evoked dynamic weight bearing was evaluated using a pressure sensor system (Bioseb DWB 2.0), mechanical allodynia using Von Frey filaments, and transcriptional changes at the dorsal root ganglion using BioRad gene array. MIA model showed mechanical allodynia of the ipsilateral paw for over 3 months. The dynamic weight bearing parameters reveal continuous compensatory weight preference towards the uninjured limbs for the same period. Unlike Von Frey, significantly different dynamic behavioral parameters begin to appear within 24 hours post MIA injection. Moreover, parameters related to weight and area distribution showed temporal changes over the course of the study. The study shows that dynamic weight bearing assessment is an effective tool to understand the long-term progression of pain behavior in a MIA model.
BIOSEB Instruments Used
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)
    [meta_description] => 
    [meta_keywords] => https://doi.org/10.1016/j.jpain.2022.03.094
    [meta_title] => 
    [link_rewrite] => comprehensive-evaluation-of-long-term-dynamic-mechanical-behavior-in-a-rat-mia-oa-model
    [actif_langue] => 1
    [read] => 778
    [count_comments] => 0
    [id] => 1558
    [categories] => Array
        (
            [70] => Array
                (
                    [id_prestablog_categorie] => 70
                    [title] => Arthrite & Arthrose
                    [link_rewrite] => Arthrite-Arthrose
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Comprehensive Evaluation of Long-term Dynamic Mechanical Behavior in a Rat MIA OA Model
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1216] => Array
                (
                    [name] => Distribution Pondérale Dynamique 2.0
                    [description_short] => 
Un système permettant l'analyse de la posture des animaux par la répartition du poids sur chacune des 4 pattes. Le DWB est un test unique dans l'étude de nombreux modèles de douleurs, principalement non évoquée , neuropathique ou encore inflammatoire ainsi que pour les études sur l'osthéoarthrite et divers affections du SNC. 

Le nouvelle version DWB2 intègre une nouvelle interface logiciel plus simple avec gestion des listes d'animaux ainsi que de nouveaux algorithmes d'analyse automatique de la posture.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-spontanee-deficit-de-posture/1216-dynamic-weight-bearing-20.html
                )

            [1877] => Array
                (
                    [name] => Dynamic Weight Bearing 2.0 – Module Postural Additionnel
                    [description_short] => 
Étendez votre analyse grâce à des calculs posturaux et locomoteurs avancés
Le système de Distribution Pondérale Dynamique (DWB2)  de BIOSEB s’enrichit avec l'ajout du Module Postural. Ce complément logiciel optionnel améliore l’analyse standard de la répartition du poids en intégrant des nouveaux calculs conçus pour l’étude de la posture, de la locomotion et de l’activité des animaux.
Développé en collaboration avec le laboratoire du Dr. Tighilet de l’Université Aix-Marseille - CNRS, le Module Postural améliore votre DWB2 en fournissant des paramètres précieux pour les recherches sur la douleur, les troubles vestibulaires et les maladies neurodégénératives.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-spontanee-deficit-de-posture/1877-dynamic-weight-bearing-20-module-postural-additionnel.html
                )

        )

)
1