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Dernière publication 03/01/2026

Neuroprotective Effects of Distilled Extract of Zanthoxylum piperitum in Parkins

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the...

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    [title] => Neuroprotective Effects of Distilled Extract of Zanthoxylum piperitum in Parkins
    [paragraph] => Neuroprotective Effects of Distilled Extract of Zanthoxylum piperitum in Parkinson’s Disease Models
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Authors
Park, Su Bin, Gong, Jihun, Yang, Gabsik, Baek, Ye-eun, Khan, Amjad, Yook, Tae Han, Jang, Ji Yong, Kim, Jong Uk

Lab
* Authors to whom correspondence should be addressed.; † These authors contributed equally to this work.; Authors to whom correspondence should be addressed.; These authors contributed equally to this work.; Primary and Hospital Care; Tourism and Hospitality
Journal
Nutrients
Abstract
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the substantia nigra. Oxidative stress, neuroinflammation, and α-synuclein aggregation are central pathological features of PD. Zanthoxylum piperitum DC, commonly known as Korean pepper or chopi, is a traditional dietary spice in Eastern Asia and has been reported to possess antioxidant and anti-inflammatory properties. This study investigated the neuroprotective and motor function–enhancing effects of distilled extract of Z. piperitum (deZP) in 1-Methyl-4-phenylpyridinium (MPP+)-treated Caenorhabditis elegans and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse models of PD. Methods: In the C. elegans model, dopaminergic neurotoxicity was induced by MPP+, and deZP was tested at 0.25, 0.5, and 1% (v/v) to evaluate neuronal preservation through GFP-labeled dopaminergic neurons and α-synuclein expression. Concurrently, in the MPTP-induced mouse model, deZP was administered intranasally at a fixed dose of 20 μL/mouse, equivalent to 5 mg/mouse. Motor function was assessed using the rota-rod test, pole test, and grip strength test, while dopaminergic neuronal survival was evaluated by tyrosine hydroxylase (TH) immunostaining. Results: In MPP+-treated C. elegans, deZP significantly restored green fluorescent protein (GFP) fluorescence in dopaminergic neurons and reduced α-synuclein expression, with the most pronounced effects observed at 1% (v/v). In the MPTP-induced mouse model, deZP at this fixed intranasal dose significantly improved motor performance and preserved TH-positive neurons in the substantia nigra. Conclusions: These findings suggest that deZP may represent a promising preclinical candidate for further investigation in PD-related neurodegeneration.
Keywords/Topics
mptp -induced mouse models; pole test; grip strength test; pd-related neurodegeneration; distilled extract; zanthoxylum piperitum; parkinson s disease; dopaminergic neurons; oxidative stress; neuroinflammation
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
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