Publications

Dernière publication 30/09/2006

IL-6 knockout mice exhibit resistance to stress-induced development of depressio

Cytokine-dependent mechanisms in the CNS have been implicated in the pathogenesis of depression. Interleukin-6 is upregulated in depressed patients...

Array
(
    [id_prestablog_news] => 84
    [id_shop] => 1
    [date] => 2006-09-30 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 168
    [id_lang] => 2
    [title] => IL-6 knockout mice exhibit resistance to stress-induced development of depressio
    [paragraph] => IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors.
    [content] => 
Authors
S. Chourbaji, A. Urani, I. Inta, C. Sanchis-Segura, C. Brandwein et al.

 Lab
Central Institute of Mental Health (ZI), J5, Mannheim, Germany ; University of Heidelberg, Department of Neurology, Heidelberg, Germany.
Journal
Neurobiology of Diseasen
Abstract
Cytokine-dependent mechanisms in the CNS have been implicated in the pathogenesis of depression. Interleukin-6 is upregulated in depressed patients and dowregulated by antidepressants. It is, however, unknown whether IL-6 is involved in the pathogenesis of depression. We subjected IL-6-deficient mice (IL-6_/_) to depression-related tests (learned helplessness, forced swimming, tail suspension, sucrose preference). We also investigated IL-6 in the hippocampus of stressed wild-type mice. IL-6_/_ mice showed reduced despair in the forced swim, and tail suspension test, and enhanced hedonic behavior. Moreover, IL-6_/_ mice exhibited resistance to helplessness. This resistance may be caused by the lack of IL-6, because stress increased IL-6 expression in wild-type hippocampi. This suggests that IL-6 is a component in molecular mechanisms in the pathogenesis of depression. IL-6_/_ mice represent tools to study IL-6-dependent signaling pathways in the pathophysiology of depression in vivo. Moreover, these mice may support the screening of compounds for depression by altering cytokine-mediated signaling.
BIOSEB Instruments Used
Tail Suspension Test - Wireless (BIO-TST5)

Keywords/Topics
Dépression; Stress; Troubles de l'humeur
    [meta_description] => 
    [meta_keywords] => http://www.sciencedirect.com/science/article/pii/S096999610600115X
    [meta_title] => 
    [link_rewrite] => il-6-knockout-mice-exhibit-resistance-to-stress-induced-development-of-depression-like-behaviors-
    [actif_langue] => 1
    [read] => 1127
    [count_comments] => 0
    [id] => 84
    [categories] => Array
        (
            [57] => Array
                (
                    [id_prestablog_categorie] => 57
                    [title] => Dépression
                    [link_rewrite] => Depression
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [58] => Array
                (
                    [id_prestablog_categorie] => 58
                    [title] => Stress
                    [link_rewrite] => Stress
                )

            [15] => Array
                (
                    [id_prestablog_categorie] => 15
                    [title] => Troubles de l'humeur
                    [link_rewrite] => Troubles-de-l-humeur
                )

        )

    [authors] => 
    [paragraph_crop] => IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors.
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [2] => Array
                (
                    [name] => Test de suspension caudale automatique- Sans-fil
                    [description_short] => 
La version 5 du Test de Suspension Caudale de Bioseb, basée sur des capteurs de force ainsi que sur de l'acquisition vidéo, est la seule et unique solution totalement automatisée au monde pour effectuer un test de désespoir comportemental simple et objectif sur souris. Il s'agit d'une méthode rapide, fiable et sans douleur pour tester les effets psychotropes de drogues et substances comme les antidépresseurs et les sédatifs. Ce test classique et indolore pour la recherche sur l'anxiété et la dépression est désormais présenté avec un nouveau logiciel puissant et moderne, dans une version sans-fil BlueTooth.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/anxiete-depression/2-tail-suspension-test-wireless.html
                )

        )

)
1