Publications

Dernière publication 22/06/2026

Bottlebrush polymer conjugates for enhanced antisense oligonucleotide therapy in

. Oligonucleotides are a promising class of genetic medicine for myotonic dystrophy type 1 (DM1), the most common adult-onset muscular dystrophy. H

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    [title] => Bottlebrush polymer conjugates for enhanced antisense oligonucleotide therapy in
    [paragraph] => Bottlebrush polymer conjugates for enhanced antisense oligonucleotide therapy in myotonic dystrophy type 1
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Authors
Li, Yao, Oetheimer, Christopher, Wang, Yuyan, Heo, Gyu Seong, Wu, Jiaqi, Chang, Rong, Zhang, Wei, Schneider, Elle, Chen, Junjie, Fang, Yang, Wei, Yun, Nian, Keqing, Zhang, Hengli, Sherman, Lauren, Liu, Yongjian, Zhang, Ke

Lab
pacDNA Inc.; Natick; MA 01760; United States; Department of Bioengineering; Northeastern University; Department of Biology; Northeastern University; College of Professional Studies; Northeastern University; Department of Chemical Engineering; Northeastern University; Copyright © 2026 Oxford University Press; University press partners; Oxford University Press; University of Oxford
Journal
Nucleic Acids Research
Abstract
Abstract. Oligonucleotides are a promising class of genetic medicine for myotonic dystrophy type 1 (DM1), the most common adult-onset muscular dystrophy. H
Keywords/Topics
hindlimb grip strength; bottlebrush polymer conjugates; enhanced antisense oligonucleotide therapy; myotonic dystrophy type; oligonucleotides; genetic medicine; h forelimb; bioseb; baseline
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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