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Dernière publication 19/10/2021

Loss of REDD1 prevents chemotherapy-induced muscle atrophy and weakness in mice

Chemotherapy is an essential treatment to combat solid tumours and mitigate metastasis. Chemotherapy causes side effects including muscle wasting...

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    [title] => Loss of REDD1 prevents chemotherapy-induced muscle atrophy and weakness in mice
    [paragraph] => Loss of REDD1 prevents chemotherapy-induced muscle atrophy and weakness in mice
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Authors
BA Hain, H Xu, DL Waning 

 Lab
Dept. of Cellular and Molecular Physiology, The Penn State College of Medicine, Hershey, PA, USA
Journal
Journal of Cachexia, Sarcopenia and Muscle
Abstract
 Chemotherapy is an essential treatment to combat solid tumours and mitigate metastasis. Chemotherapy causes side effects including muscle wasting and weakness. Regulated in Development and DNADamage Response 1 (REDD1) is a stress-response protein that represses the mechanistic target of rapamycin (mTOR) in complex 1 (mTORC1), and its expression is increased in models of muscle wasting. The aim of this study was to determine if deletion of REDD1 is sufficient to attenuate chemotherapy-induced muscle wasting and weakness in mice.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Atrophie musculaire; Cancer
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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