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Dernière publication 26/01/2011

Beneficial behavioural and neurogenic effects of agomelatine in a model of depre

Agomelatine (S20098) is a novel antidepressant drug with melatonergic agonist and 5-HT2C receptor antagonist properties, displaying...

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    [title] => Beneficial behavioural and neurogenic effects of agomelatine in a model of depre
    [paragraph] => Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety.
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Authors
Q. Rainer, L. Xia, JP. Guilloux, C. Gabriel, DJ. David et al

 Lab
Université Paris-Sud, Laboratoire Neuropharmacologie, Châtenay-Malabry, France.
Journal
International journal of neuropsychology
Abstract
Agomelatine (S20098) is a novel antidepressant drug with melatonergic agonist and 5-HT2C receptor antagonist properties, displaying antidepressant/anxiolytic-like properties in animal models and in humans. In a depression/anxiety-like mouse model in which the response of the HPA axis is blunted, we investigated whether agomelatine could reverse behavioural deficits related to depression/anxiety compared to the classical selective serotonin reuptake inhibitor, fluoxetine. Adult mice were treated for 8 wk with either vehicle or corticosterone (35 μg/ml.d) via drinking water. During the final 4 wk, animals were treated with vehicle, agomelatine (10 or 40 mg/kg i.p.) or fluoxetine (18 mg/kg i.p.) and tested in several behavioural paradigms and also evaluated for home-cage activity. Our results showed that the depressive/anxiety-like phenotype induced by corticosterone treatment is reversed by either chronic agomelatine or fluoxetine treatment. Moreover, agomelatine increased the dark/light ratio of home-cage activity in vehicle-treated mice and reversed the alterations in this ratio induced by chronic corticosterone, suggesting a normalization of disturbed circadian rhythms. Finally, we investigated the effects of this new antidepressant on neurogenesis. Agomelatine reversed the decreased cell proliferation in the whole hippocampus in corticosterone-treated mice and increased maturation of newborn neurons in both vehicle- and corticosterone-treated mice. Overall, the present study suggests that agomelatine, with its distinct mechanism of action based on the synergy between the melatonergic agonist and 5-HT2C antagonist properties, provides a distinct antidepressant/anxiolytic spectrum including circadian rhythm normalization.
BIOSEB Instruments Used
Forced Swimming Test: New FST DUAL SENSOR (BIO-FST-DSM)

Keywords/Topics
Anxiété; Dépression; Troubles de l'humeur
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En combinant une double acquisition, vibrations et trace vidéo,
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fiber_new Possibilité d’ajouter la mesure de l’activité verticale des animaux dans la cage (en option).

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