Publications

Dernière publication 30/11/2011

Erythropoietin Restores C-Fiber Function and Prevents Pressure Ulcer Formation i

Pressure-induced vasodilatation (PIV), a cutaneous physiological neurovascular (C-fiber/endothelium) mechanism, is altered in diabetes and could...

Array
(
    [id_prestablog_news] => 354
    [id_shop] => 1
    [date] => 2011-11-30 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 704
    [id_lang] => 2
    [title] => Erythropoietin Restores C-Fiber Function and Prevents Pressure Ulcer Formation i
    [paragraph] => Erythropoietin Restores C-Fiber Function and Prevents Pressure Ulcer Formation in Diabetic Mice. 
    [content] => 
Authors
C. Demiot, V. Sarrazy, J. Javellaud, L. Gourloi, L. Botelle et al. 

 Lab
Université de Limoges, Institut Fédératif de Recherche, Faculté de Médecine et de Pharmacie, Limoges, France. 
Journal
Journal of Investigative Dermatology
Abstract
Pressure-induced vasodilatation (PIV), a cutaneous physiological neurovascular (C-fiber/endothelium) mechanism, is altered in diabetes and could possibly contribute to pressure ulcer development. We wanted to determine whether recombinant human erythropoietin (rhEPO), which has protective neurovascular effects, could prevent PIV alteration and pressure ulcer formation. We developed a skin pressure ulcer model in mice by applying two magnetic plates to the dorsal skin. This induced significant stage 2 ulcers (assessed visually and histologically) in streptozotocin-treated mice with 8 weeks of diabetes compared with very few in controls. Control and streptozotocin mice received either no treatment or systematic rhEPO (3,000_UI_kg(-1) intraperitoneally, twice a week) during the last 2 weeks of diabetes. After 8 weeks of diabetes, we assessed ulcer development, PIV, endothelium-dependent vasodilation, C-fiber-mediated nociception threshold, and skin innervation density. Pretreatment with rhEPO fully prevented ulcer development in streptozotocin mice and also fully restored C-fiber nociception, skin innervation density, and significantly improved PIV, but had no effect on endothelium-dependent vasodilation. Our finding that rhEPO treatment protects the skin against pressure-induced ulcers in diabetic mice encourages evaluation of the therapeutic potential for non-hematopoietic analogs of EPO in preventing neuropathic diabetic ulcers.
BIOSEB Instruments Used
SMALGO: SMall animal ALGOmeter (BIO-SMALGO),Rodent pincher - analgesia meter (BIO-RP-M)

Keywords/Topics
Domaines de recherche divers
    [meta_description] => 
    [meta_keywords] => http://www.nature.com/jid/journal/v131/n11/full/jid2011211a.html
    [meta_title] => 
    [link_rewrite] => erythropoietin-restores-c-fiber-function-and-prevents-pressure-ulcer-formation-in-diabetic-mice--
    [actif_langue] => 1
    [read] => 1317
    [count_comments] => 0
    [id] => 354
    [categories] => Array
        (
            [26] => Array
                (
                    [id_prestablog_categorie] => 26
                    [title] => Domaines de recherche divers
                    [link_rewrite] => Domaines-de-recherche-divers
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Erythropoietin Restores C-Fiber Function and Prevents Pressure Ulcer Formation in Diabetic Mice. 
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1207] => Array
                (
                    [name] => SMALGO: Analgésimètre pour petits animaux - Sans fil
                    [description_short] => 
Dédié aux petits animaux tels que les rats et les souris, le Smalgo est un algomètre (ou analgésimètre) à pression conçu pour faciliter l'évaluation de seuils de sensibilité. Il s'agit d'un outil indispensable pour les études sur l'arthrose et la douleur. Un instrument rapide, facile d'utilisation et fiable pour évaluer le seuil de sensibilité à la douleur chez l'animal par l'application d'une force progressive, qui peut également être utilisé pour le screening de substances pharmacologiques, le phénotypage, ainsi que les études sur les neuropathies, les inflammations et les douleurs post-opératoires. Maintenant en version sans-fil, pour être libéré des câbles!

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1207-smalgo-small-animal-algometer.html
                )

            [1218] => Array
                (
                    [name] => Algomètre à pince instrumentée pour rongeurs - Sans fil
                    [description_short] => 
Un algomètre rapide et précis, basé sur une pince instrumentée: une alternative au test de Randall-Selitto. Ce nouvel algésimètre développé par Bioseb selon Luis-Delgado et al. (2005) permet des tests nociceptifs précis et la mesure du seuil de douleur mécanique sur pattes de rats ou de souris, avec une contrainte minimale. Maintenant en version sans-fil, pour être libéré des câbles!

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1218-rodent-pincher-analgesia-meter.html
                )

        )

)
1