Publications

Dernière publication 03/02/2020

Deficiency of complement component C1Q prevents cerebrovascular damage and white

Age-related cognitive decline and many dementias involve complex interactions of both genetic and environmental risk factors. Recent evidence has...

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    [title] => Deficiency of complement component C1Q prevents cerebrovascular damage and white
    [paragraph] => Deficiency of complement component C1Q prevents cerebrovascular damage and white matter loss in a mouse model of chronic obesity
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Authors
L Graham, H Kocalis, I Soto, G Howell

 Lab
The Jackson Laboratory, Bar Harbor, ME USA
Journal
bioRxiv
Abstract
Age-related cognitive decline and many dementias involve complex interactions of both genetic and environmental risk factors. Recent evidence has demonstrated a strong association of obesity with the development of dementia. Furthermore, white matter damage is found in obese subjects and mouse models of obesity. Here, we found that components of the complement cascade, including C1QA and C3 are increased in the brain of western diet (WD)-fed obese mice, particularly in white matter regions. To functionally test the role of the complement cascade in obesity induced brain pathology, female and male mice deficient in complement component 1qa (C1QA), an essential molecule in the activation of the classical pathway of the complement cascade, were fed a WD and compared to WD fed WT mice, and to C1qa knockout (KO) and WT mice fed a control diet (CD). C1qa KO mice fed a WD became obese but did not show pericyte loss or a decrease in laminin density in the cortex and
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Obésité & Surpoids; Métabolisme
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
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