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Dernière publication 30/04/2026

Revisiting MAC as a static measure of anaesthesia: evidence for dynamic response

The presence of a righting reflex is known to vary over time in an individual at the population half-maximal effective anaesthetic concentration (EC50

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    [title] => Revisiting MAC as a static measure of anaesthesia: evidence for dynamic response
    [paragraph] => Revisiting MAC as a static measure of anaesthesia: evidence for dynamic responses under isoflurane in male mice
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Authors
Aden Mandel, Jackson Soohoo, Chloe Deitelzweig, Isha Patkar, Dennis Han, Madona Farag, Andrew McKinstry-Wu

Lab
Laboratory Investigation
Journal
British Journal of Anaesthesia
Abstract
The presence of a righting reflex is known to vary over time in an individual at the population half-maximal effective anaesthetic concentration (EC50
Keywords/Topics
male mice; half-maximal effective anaesthetic concentration; calibrated forceps; anaesthesia; evidence; dynamic responses; isoflurane; time; ec50 paw pinches; bioseb

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Un algomètre rapide et précis, basé sur une pince instrumentée: une alternative au test de Randall-Selitto. Ce nouvel algésimètre développé par Bioseb selon Luis-Delgado et al. (2005) permet des tests nociceptifs précis et la mesure du seuil de douleur mécanique sur pattes de rats ou de souris, avec une contrainte minimale. Maintenant en version sans-fil, pour être libéré des câbles!


Instrument for ratsInstrument for mice

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