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Dernière publication 24/09/2021

Computational Approach Reveals Pronociceptive Potential of Cannabidiol in Osteoa

Systems pharmacology employs computational and mathematical methods to study the network of interactions a drug may have within complex biological...

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    [title] => Computational Approach Reveals Pronociceptive Potential of Cannabidiol in Osteoa
    [paragraph] => Computational Approach Reveals Pronociceptive Potential of Cannabidiol in Osteoarthritis- Role of Transient Receptor Potential Channels
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Authors
J Mlost, M K_dziora, K Starowicz

 Lab
Department of Neurochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland
Journal
Pharmaceuticals
Abstract
Systems pharmacology employs computational and mathematical methods to study the network of interactions a drug may have within complex biological pathways. These tools are well suited for research on multitarget drugs, such as natural compounds, in diseases with complex etiologies, such as osteoarthritis (OA). The present study focuses on cannabidiol (CBD), a non-psychoactive constituent of cannabis, targeting over 60 distinct molecular targets as a potential treatment for OA, a degenerative joint disease leading to chronic pain with a neuropathic component. We successfully identified molecular targets of CBD that were relevant in the context of OA treatment with both beneficial and detrimental effects. Our findings were confirmed by in vivo and molecular studies. A key role of PPARgamma in mediating the therapeutic potential of CBD was revealed, whereas upregulation of multiple transient receptor potential channels demasked CBD-induced heat hyperalgesia. Our findings pave the way for novel CBD-based therapy with improved therapeutic potential but also encourage the use of bioinformatic tools to predict the mechanism of action of CBD in different conditions. We have also created an accessible web tool for analogous analysis of CBD pharmacology in the context of any disease of interest and made it publicly available.
BIOSEB Instruments Used
Kinetic Weight Bearing (BIO-KWB-DUAL)

Keywords/Topics
Arthrite & Arthrose
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Un instrument unique qui ne fournit pas seulement la mesure indépendante et automatisée du poids porté par chaque patte d'un rongeur (rat ou souris) évoluant librement, comme le Test de Distribution Pondérale Dynamique, mais génère aussi des courbes d'informations sur la distribution de cette force dans le temps, toujours indépendamment et pour chaque patte.

Un instrument révolutionnaire pour vos recherches en analgésie, nociception et neurosciences, particulièrement adapté aux travaux sur les maladies de Parkinson et d'Alzheimer, l'arthrite et les lésions du cerveau et de la moelle épinière.

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