Publications

Dernière publication 01/01/2025

Molecular and Functional Recovery in Contused Muscle Tissues Treated with Betuli

Muscle contusion injuries are common in trauma and sports medicine, often resulting in prolonged recovery and functional impairment. This study...

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    [title] => Molecular and Functional Recovery in Contused Muscle Tissues Treated with Betuli
    [paragraph] => Molecular and Functional Recovery in Contused Muscle Tissues Treated with Betulin in Mice
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Authors
Dr. Maria S. Kovalenko, Dr. Elena I. Smirnova

 Lab

Journal
International Research Journal of Medical Sciences and Health Care
Abstract
Muscle contusion injuries are common in trauma and sports medicine, often resulting in prolonged recovery and functional impairment. This study investigates the therapeutic efficacy of betulin—a natural pentacyclic triterpene—on the molecular and functional recovery of skeletal muscle following contusion injury in mice. Using a controlled murine injury model, betulin was administered post-injury, and recovery was evaluated through histological analysis, inflammatory marker profiling, and BIO-GS3ing. The results revealed that betulin significantly reduced inflammation, promoted myofiber regeneration, and accelerated functional recovery compared to untreated controls. Molecular assays demonstrated upregulation of regenerative markers and downregulation of pro-inflammatory cytokines in treated tissue. These findings suggest that betulin facilitates both structural and functional muscle repair and holds promise as a novel therapeutic agent for soft tissue injuries.
Keywords/Topics
Betulin; muscle regeneration; contusion injury; skeletal muscle; inflammation; functional recovery; tissue repair; natural compounds; mice model; triterpenes
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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