Publications

Dernière publication 06/03/2020

Dose-dependent and long-term cerebroprotective effects of intranasal delivery of

Intranasal administration is emerging as a very promising route to deliver therapeutics to the brain. We have recently shown that the intranasal...

Array
(
    [id_prestablog_news] => 1239
    [id_shop] => 1
    [date] => 2020-03-06 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2436
    [id_lang] => 2
    [title] => Dose-dependent and long-term cerebroprotective effects of intranasal delivery of
    [paragraph] => Dose-dependent and long-term cerebroprotective effects of intranasal delivery of progesterone after ischemic stroke in male mice
    [content] => 
Authors
M Fréchou, X Zhu, P Liere, A Pianos, M Schumacher et al

 Lab
U1195 Inserm and University Paris-Sud and University Paris-Saclay, Kremlin-Bicêtre, France
Journal
Neuropharmacology
Abstract
Intranasal administration is emerging as a very promising route to deliver therapeutics to the brain. We have recently shown that the intranasal delivery of progesterone at 8 mg/kg is neuroprotective after stroke in male mice. To explore the translational potential of intranasal progesterone treatment, we performed a dose-response study and analyzed outcomes at 48 h after middle cerebral artery occlusion (MCAO). The effects on functional outcomes at long-term were examined by using the optimal dose. In the first experiment, male C57BL/6JRj mice were treated with progesterone at 8, 16 or 24 mg/kg, or with placebo at 1, 6 and 24 h post-MCAO. Our results show that the dose of 8 mg/kg was optimal in counteracting the early histopathological impairments as well as in improving functional recovery. Steroid profiling in plasma showed that the dose of 8 mg/kg is the one that leads to sustained high levels of progesterone and its neuroactive metabolites. In the second experiment, the dose of 8 mg/kg was used and analyzes were performed at 2, 7 and 21 days post-MCAO. Progesterone increased survival, glycemia and body weight. Furthermore, progesterone decreased neurological deficits and improved performances of mice on the rotarod and pole as early as 2 days and up to 21 days post-MCAO. These findings show that intranasal administration of progesterone has a significant translational potential as a cerebroprotective treatment after stroke that can be effective to reduce mortality, to limit tissue and cell damage at the acute phase; and to confer a long-term functional recovery.
BIOSEB Instruments Used
Aron Test or Four Plates Test (LE830),Rotarod (BX-ROD)
    [meta_description] => 
    [meta_keywords] => https://www.sciencedirect.com/science/article/abs/pii/S0028390820301040#!
    [meta_title] => 
    [link_rewrite] => dose-dependent-and-long-term-cerebroprotective-effects-of-intranasal-delivery-of-progesterone-after-ischemic-stroke-in-male-mice
    [actif_langue] => 1
    [read] => 996
    [count_comments] => 0
    [id] => 1239
    [categories] => Array
        (
            [40] => Array
                (
                    [id_prestablog_categorie] => 40
                    [title] => Accidents ischémiques transitoires (AIT)
                    [link_rewrite] => Accidents-ischemiques-transitoires-AIT
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [11] => Array
                (
                    [id_prestablog_categorie] => 11
                    [title] => Système Nerveux Central (SNC)
                    [link_rewrite] => Systeme-Nerveux-Central-SNC
                )

        )

    [authors] => 
    [paragraph_crop] => Dose-dependent and long-term cerebroprotective effects of intranasal delivery of progesterone [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [588] => Array
                (
                    [name] => Test d'Aron ou 'Four Plates Test'
                    [description_short] => 
Le 'Four Plates Test' ou test d'Aron est une exclusivité Bioseb!
Un outil rapide pour l'évaluation de substances anxiolytiques putatives chez l'animal naïf. Un "must" pour l'étude de l'anxiété, le screening des drogues et le phénotypage.
                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/anxiete-depression/588-aron-test-or-four-plates-test.html
                )

            [1326] => Array
                (
                    [name] => Rotarod pour rats et souris
                    [description_short] => 
Le Rotarod offre une méthode facile pour le test de l'activité motrice chez les rongeurs (rats ou souris) - une solution idéale pour étudier les lésions du système nerveux central (SNC), les effets de différentes pathologies et substances pharmacologiques sur l'activité motrice, la résistance à la fatigue, etc. Désormais encore plus simple d'utilisation! La nouvelle interface utilisateur graphique et tactile permet une visualisation claire de la vitesse et des temps associés à chaque piste. Vous pouvez maintenant changer de mode, régler la vitesse et créer des protocoles directement depuis l'écran principal for une une plus grande flexibilité et un maximum de fonctionnalités.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/activite-systeme-moteur-coordination/1326-rotarod.html
                )

        )

)
1