Activity, Motor Control & Coordination
Pain - Thermal Allodynia / Hyperalgesia
Pain - Spontaneous Pain - Postural Deficit
Pain - Mechanical Allodynia / Hyperalgesia
Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
Metabolism - Food & Drink Intake
Automated 3D Open Field for Rats and Mice
A unique setup for the automation of the Open Field test for rats and mice : 3D-camera based...
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Pain
Central Nervous System (CNS)
Neurodegeneration
Sensory system
Motor control
Mood Disorders
Other disorders
Muscular system
Joints
Metabolism
Cross-disciplinary subjects
CONFERENCES & MEETINGS 
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Operant & Behavior Modular System
An entirely modular experimental enclosure designed to conduct operant conditioning procedures (e.g. food reinforcement, DMTS, conflict tests, self-administrationâ€_) on rodents (rats and mice). A powerful tool for studies on Anxiety, Drug screening, Phenotyping Anhedonia, Drug dependence, Alcohol dependence, and much more. System can also be built for teaching applications.
Presentation
A setup example
for our Operant/Behavior Chambers
Operating principleThe operant chamber is made in an entirely modular structure which allows complete disassembling or rearrangement to build a new space of different dimensions/components or to enable storage in the minimum space. It can be easily transformed from rat chamber to mice chamber (or vice versa) with a reduced cost.
A frontal door offers a total accessibility inside the chamber. Walls and cover can be of different material or colour, since they are totally removable.
Each chamber is associated with a Link Box which provides power to up to 8 (expandable to 16) Operant Modules (levers, lights, sound, dispensers, electrical shock...) conferring to the chambers a full autonomy.
The Cages can be equipped with a Weigh Transducer in order to record activity or freezing.
Research protocole examples| Food-motivated operant conditioning test Progressive-ratio (PR) schedules permit studying food-motivated behavior. These schedules require an increasing number of operant responses to obtain successive rewards within a session. For example, a typical PR 5 schedule requires five responses to produce the first reinforcer, and the response requirement is incremented by five each time a reinforcer is earned. The breaking point, defined as the highest ratio completed is a classical measure reflecting the efficacy or motivational strength of food, and is increased in response to food-deprivation or reward high palatability. | Self-administration test Self administration is a classical model of human drug-taking behavior and consists in establishing in rodents an operant conditioning of an instrumental response (nose-poke, lever pressure) to obtain a reward, according to a fix or progressive ratio. Self administration is a standard paradigm for studying the acute rewarding properties of drugs, the development of habitual drug-seeking behaviors, and ultimately, addiction. Moreover, this method can be used to assess the abuse potential of drugs. | Geller Seifter test The Geller-Seifter paradigm is a conflict model in which prior food-deprived rodents have to “choose” between consuming food and avoiding the punishment associated with this consumption. Basically, periods of responding by lever pressing to get sweetened condensed milk on a variable interval schedule are interrupted by periods where, in the presence of a signal, reward can be obtained more frequently but are accompanied by mild footshocks. Levels of punished responding are inversely proportional to the level of anxiety. Then, in this context, the shock-induced reduction of reward seeking can be reversed by administration of anxiolytics. |
 Parameters Measured• Number of responses (LE 85XCT) • Number of reinforcements (LE 85XCT) • And many user-defined parameters (see PackWin software)  Key features• Entirely modular system • Easily transformed from rat to mice chamber • Reduced number of cables • Possibility of customization • Up to 8 stations can be connected at once to PC through a single cable |  Domains of application• Anxiety • Drug screening • Phenotyping • Anhedonia • Drug dependence • Alcohol dependence • and much more... |
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