Activity, Motor Control & Coordination
Pain - Thermal Allodynia / Hyperalgesia
Pain - Spontaneous Pain - Postural Deficit
Pain - Mechanical Allodynia / Hyperalgesia
Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
Metabolism - Food & Drink Intake
Pain
Central Nervous System (CNS)
Neurodegeneration
Sensory system
Motor control
Mood Disorders
Other disorders
Muscular system
Joints
Metabolism
Cross-disciplinary subjects
Preclinical studies and opioids: role in crisis management in the United States Authors
Y. Sevelinges, F. Lévy, A.-M. Mouly, G. Ferreira.
Lab
Laboratoire de Comportement, Neurobiologie et Adaptation, UMR 6175, INRA-CNRS-Université de Tours-Haras Nationaux, F-37380 Nouzilly, France
Journal
Behavioural Brain Research
Abstract
The aim of the present study was to investigate whether neonatal odor experience associated with the mother affects food avoidance learning and basolateral amygdala (BLA) involvement in adulthood. Odorization of mother's nipples with banana or almond solutions from birth to weaning resulted in an impairment at adulthood of conditioned odor aversion (COA). These effects were specific to the early-experienced odor since no deficit was observed for COA to a novel odor (Experiment 1). In contrast, mere exposure to an odor in the home cage instead of on mother's nipples induced no deficit in COA at adulthood (Experiment 2). Finally, transitory inactivation of the BLA during COA acquisition in adult animals impaired the normal COA of naïve animals but also the attenuated COA of rats with early odor experience on the mother (Experiment 3). These results demonstrate that neonatal odor experience associated with the mother promotes the acquisition of appetitive memories which can interfere with food avoidance learning in adulthood. They also suggest that this early experience did not modify the BLA involvement in learned aversion.