Activity, Motor Control & Coordination

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Grip strength test

An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins,...

Acquisition software: ACTITRACK

Together with IR ACTIMETER LE8811, this software controls data acquisition for one to 32 LE8815 systems and process data analysis

Description

Bioseb's instruments are recognised and widely adopted by the international scientific community, as demonstrated by numerous peer-reviewed publications. These studies highlight the essential role of our tools in advancing knowledge of motor deficits, neurodegenerative diseases and rehabilitation strategies. Here are a few outstanding examples of research that has successfully used our solutions.

In 2022, a scientific team from the Department of Pharmacological and Biomolecular Sciences at the Università degli Studi di Milano identified novel potential targets for anorexia nervosa (AN). The scientists used the Activity-Based Anorexia (ABA) rat model, with Bioseb's Spontaneous activity wheels which enabled precise monitoring of hyperactivity, a key symptom of AN. These findings may help to more effectively guide treatments aimed at improving, at least partially, the cognitive effects of this psychopathology.

Mottarlini F, Targa G, Bottan G, Tarenzi B, Fumagalli F, Caffino L. Cortical reorganization of the glutamate synapse in the activity-based anorexia rat model: Impact on cognition. J Neurochem. 2022 May;161(4):350-365.

A recent American study (2024) from the Department of Neurosciences, Lerner Research Institute, at Cleveland Clinic, investigated the role of suppressor of cytokine signaling-3 (SOCS3) in the progression of amyotrophic lateral sclerosis (ALS). The results revealed that SOCS3 upregulation is directly linked to increased astrogliosis, neuroinflammation, and progressive neuronal loss in ALS models, highlighting its pivotal role in disease pathogenesis and potential therapeutic target. To assess motor function decline, the researchers utilized Bioseb's Rotarod for rats and mice and Grip strength test, two essential tools for preclinical evaluation in ALS models.

Lin CY, Vanoverbeke V, Trent D, Willey K, Lee YS. The Spatiotemporal Expression of SOCS3 in the Brainstem and Spinal Cord of Amyotrophic Lateral Sclerosis Mice. Brain Sci. 2024 May 31;14(6):564.

From spontaneous to forced activity, our tools simplify data collection, reduce observer bias, and enhance reproducibility. With advanced analytical software and automated scoring systems, they detect and quantify even subtle changes in motor performance. Compatible with intuitive and powerful software suites, they are effortlessly integrated into preclinical workflows.

Whether investigating fundamental pathophysiological mechanisms or evaluating pharmacological interventions, our instruments provide reliable, reproducible, and high-quality data.

FAQ

1. What types of research applications can these instruments support?

These tools are invaluable for a range of applications, including studying neurodegenerative disorders (e.g., Parkinson’s, ALS, Huntington’s), spinal cord injuries, peripheral nerve injuries, muscular dystrophies, and the impact of therapeutic interventions or rehabilitation strategies on motor function and coordination.

2. How do automated systems like the OF3C and Automatic Ladder Test reduce observer bias?

Automated systems rely on advanced image processing and software algorithms to detect and analyze rodent movements objectively. This approach minimizes human intervention, ensuring consistent, accurate, and reproducible results while reducing the potential for subjective scoring errors.

3. Can these instruments be used for long-term studies?

Many of our products, such as the Spontaneous Activity Wheels and Activmeter, are equipped to support long-term studies by providing continuous monitoring of activity in the animal’s home cage. These devices are designed with integrated food and water systems to facilitate extended experiments. However, it is important to note that individual housing, could be stressful for the animals, and must be approved in advance by the relevant regulatory authorities within the laboratory

4. Which species are compatible with these devices?

Most instruments are optimized for mice and rats. Systems like the Rotarod can be adapted to different species, and the treadmill platforms often offer customizable lanes for a range of rodent sizes. Consult Bioseb for specifics on cross-species adaptability.

5. How do I integrate data from these instruments with other experimental measurements?

All Bioseb devices produce data in formats compatible with common data analysis and statistical software packages. This flexibility allows you to correlate locomotor, strength, or coordination parameters with other measurements—such as imaging, electrophysiology, or molecular markers—to gain a comprehensive view of the experimental outcomes.

6. Are these tests stressful for the animals?

Many of our solutions, including spontaneous activity wheels and the OF3C system, enable naturalistic, low-stress observation of behavior. Even tests that require handling (like the Grip Strength Test or Treadmill) are designed to minimize distress, and training protocols can be implemented to ensure animals acclimate comfortably.

7. What kind of technical support and training does Bioseb provide?

Bioseb offers technical support and training services upon request, tailored to the specific needs of each instrument. This includes assistance with installation, hardware and software training, and protocol optimization, depending on the complexity of the equipment. For more information or to request support, please contact us via our contact form

Activity, Motor Control & Coordination

Grip strength test

Acquisition software: ACTITRACK

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