5-HT2C agonism as a neurotherapeutic for sarcopenia- preclinical proof of concept

Authors
Kerr, Nathan R., Dashtmian, Anna R., Darvishi, Fereshteh B., Brennan, Charles D., Ayyagari, Sindhuja N., Moore, Peter J., Viteri, Jose A., Wang, Meifang, Rich, Mark M., Clark, Brian C., David Arnold, W.


Lab

Journal
GeroScience

Abstract
Sarcopenia, the pathological age-related loss of muscle mass and strength, contributes to physical decline, frailty, and diminished healthspan. The impact

Keywords/Topics
Sarcopenia; Motor neuron excitability; 5-HT2Creceptor agonism; Lorcaserin; Neurotherapeutics; Age-related muscle weakness

BIOSEB Instruments Used:
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)

Source :

https://link.springer.com/article/10.1007/s11357-025-01519-7

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