Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis symptoms and pathology in mice

Authors
Mouna Haidar, Aida Viden, Christin Daniel, Brittany Cuic, Taide Wang, Marius Rosier, Doris Tomas, Samuel A. Mills, Alistair Govier-Cole, Elvan Djouma, Nirma D. Perera, Sophia Luikinga, Valeria Rytova, Samantha K. Barton, David G. Gonsalvez, Lucy M. Palmer, Catriona McLean, Matthew C. Kiernan, Steve Vucic, Bradley J. Turner


Lab

Journal
Progress in Neurobiology

Abstract
Degeneration of both upper motor neurons in the brain and lower motor neurons in the spinal cord defines amyotrophic lateral sclerosis (ALS), but how …

Keywords/Topics
Amyotrophic lateral sclerosis;upper motor neurons;hyperexcitability;chemogenetics;mouse models

BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

Source :

https://www.sciencedirect.com/science/article/pii/S0301008225001005

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