Curcumin alleviates SNI-induced neuropathic pain by regulating the AMPK/PGC-1α signaling axis in the spinal cord

Authors
Qian Zhou, Xin Li, Wang Li, Kai Song, Xiaojun Zhou, Qihao Yang, Xue Bai, Chenghong Sun


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Abstract
Neuropathic pain, a chronic and prevalent condition, imposes significant psychological burdens on patients and society. There is an urgent need to improve pain management strategies and develop new analgesic drugs. Traditional Chinese Medicine (TCM) has gained popularity for pain relief. Curcumin (Cur), a phenolic compound derived from the rhizome of Curcuma longa, exhibits potent antioxidant, anti-cancer, and anti-inflammatory properties. However, the mechanisms by which Cur alleviates neuropathic pain remain poorly understood, and a comprehensive understanding of its therapeutic effects is still lacking.

Keywords/Topics
sni-induced neuropathic pain; pain management strategies; pain relief; mechanical allodynia; thermal hyperalgesia; curcumin; axis; significant psychological burdens; patients; society

Source :

https://www.researchsquare.com/article/rs-9821744/latest

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