Decreased opioid receptor availability and impaired neurometabolic coupling as signatures of morphine tolerance in male rats- A positron emission tomography study

Authors
Amélie Soyer, Sarah Leterrier, Sébastien Goutal, Cassandre Corvo, Wadad Saba, Fabien Caillé, Gregory Dal Bo, Alexandra Winkeler, Karine Thibault, Claire Leroy, Nicolas Tournier


Lab

Journal
Biomedicine & Pharmacotherapy

Abstract
Translational neuroimaging techniques are needed to address the impact of opioid tolerance on brain function and quantitatively monitor the impaired n…

Keywords/Topics
PET imaging ;Tolerance; Opioid; Neuroreceptor imaging; Neurometabolic; Rodent; Buprenorphine

BIOSEB Instruments Used:
Cold Hot Plate Test (BIO-CHP),Grip strength test (BIO-GS4)

Source :

https://www.sciencedirect.com/science/article/pii/S0753332225000423

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