Activity, Motor Control & Coordination
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Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
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Central Nervous System (CNS)
Neurodegeneration
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Cross-disciplinary subjects
Preclinical studies and opioids: role in crisis management in the United States Authors
L Graham, H Kocalis, I Soto, G Howell
Lab
The Jackson Laboratory, Bar Harbor, ME USA
Journal
bioRxiv
Abstract
Age-related cognitive decline and many dementias involve complex interactions of both genetic and environmental risk factors. Recent evidence has demonstrated a strong association of obesity with the development of dementia. Furthermore, white matter damage is found in obese subjects and mouse models of obesity. Here, we found that components of the complement cascade, including C1QA and C3 are increased in the brain of western diet (WD)-fed obese mice, particularly in white matter regions. To functionally test the role of the complement cascade in obesity induced brain pathology, female and male mice deficient in complement component 1qa (C1QA), an essential molecule in the activation of the classical pathway of the complement cascade, were fed a WD and compared to WD fed WT mice, and to C1qa knockout (KO) and WT mice fed a control diet (CD). C1qa KO mice fed a WD became obese but did not show pericyte loss or a decrease in laminin density in the cortex and
BIOSEB Instruments Used:
Grip strength test (BIO-GS3)
