Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a_synuclein in mouse brain

Authors
V Samantha Sykioti, M Karampetsou, I Chalatsa et al


Lab
Center for Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece

Journal
Journal of Neurochemistry

Abstract
Several lines of evidence indicate that the propagation of misfolded alpha_synuclein (alpha_syn) plays a central role in the progression and manifestation of ParkinsonÕs disease. Pathogenic alpha_syn species can be present in the extracellular space. Thus, the identification and modulation of the key enzymes implicated in extracellular alpha_syn turnover becomes vital.

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