Estradiol rescues male hydroxyl radical-mediated Charcot-Marie-Tooth 2Z by Morc2a stabilization through autophagy inhibition in a murine model

Authors
Kim, Ji Won, Nam, Soo Hyun, Lee, Geon Seong, Chung, Hye Yoon, Kim, Eun Young, Han, Jeong Pil, Jang, Jae-Hyung, Choi, Byung-Ok, Yeom, Su Cheong


Lab

Journal
Acta Neuropathologica

Abstract
Charcot–Marie–Tooth disease type 2Z (CMT2Z) is an inherited axonal neuropathy caused by haploinsufficiency of microrchidia CW-type zinc finger

Keywords/Topics
Charcot-Marie-Tooth type2Z; Estradiol; Hydroxyl radical; MORC2 haploinsufficiency; Neuromuscular regeneration

BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

Source :

https://link.springer.com/article/10.1007/s00401-025-02922-2

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