Gallic Acid Improves Muscular Function Through Enhanced Myoblast Myogenesis in Mice

Authors
Sangsoo Lee, Dong-Yup Han, Kee K. Kim


Lab

Journal
Food Science & Nutrition

Abstract
These findings may have particular relevance for conditions characterized by muscle weakness or dysfunction, such as sarcopenia and age-related muscle wasting. While existing studies have highlighted gallic acid as a muscle relaxant and documented its protective effects on muscle tissue, this study uniquely demonstrates gallic acid's capacity to enhance myogenesis and improve muscle function (Yu et al.2025). This suggests its potential as a natural supplement for maintaining muscle health during aging. Additionally, its presence in various foods and its established safety profile make it an attractive candidate for dietary supplementation. Several mechanisms might underlie the observed effects of gallic acid on muscle function (Asdaq et al.2021; Jin et al.2018). Previous studies have shown that phenolic compounds can modulate various signaling pathways involved in muscle development and function, including AMPK, PGC-1α, and antioxidant responses (Tanaka et al.2020; Zarei et al.2023; Jrad et al.2014). Related research has highlighted the beneficial effects of gallic acid on mitochondrial dynamics and myogenic gene expression in fully differentiated myotubes (Chang et al.2021). Notably, the observation in this study that gallic acid improved the myogenesis of myoblasts in growth medium suggests a novel mechanism whereby gallic acid may enhance signaling pathways that trigger the transition of proliferative myoblasts into the differentiation stage. This represents a distinct functional aspect of gallic acid beyond its known antioxidant properties. Although mitochondrial function and antioxidant parameters were not directly assessed in the present study, these pathways may contribute to the observed effects, particularly during the later stages of myogenesis when significant mitochondrial adaptations occur. Future studies should investigate these specific molecular mechanisms through which gallic acid enhances myogenesis and improves muscle function, with particular attention to redox signaling pathways and mitochondrial biogenesis during the transition from myoblast proliferation to differentiation.

Keywords/Topics
exercise performance; gallic acid; muscle function; myogenesis; natural supplement

BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

Source :

https://onlinelibrary.wiley.com/doi/abs/10.1002/fsn3.70667

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Grip strength test

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