Relationship between simvastatin pharmacokinetics and muscle toxicity in male mice

Authors
Jamal Bouitbir, Gerda M. Sanvee, Miljenko V. Panajatovic, Natasha Bärenzung Fehrenbach, Théo Fréchard, Madhuri Manivannan, Urs Duthaler, Stephan Krähenbühl


Lab

Journal
Food and Chemical Toxicology

Abstract
Statins are highly effective in reducing plasma LDL-cholesterol but may be myotoxic. Since the relationship between statin exposure and myotoxicity is…

Keywords/Topics
Simvastatin;Skeletal muscle;Dose-finding study;Pharmacokinetics;Exercise;Atrophy

BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

Source :

https://www.sciencedirect.com/science/article/pii/S0278691525004569

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