Reversal of cognitive deficits in FUSR521G amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction

Authors
Mari Carmen Pelaez, Frédéric Fiore, Nancy Larochelle, Afrooz Dabbaghizadeh, Mario Fernandez Comaduran, Danielle Arbour, Sandra Minotti, Laetitia Marcadet, Martine Semaan, Richard Robitaille, Josephine N. Nalbantoglu, Chantelle F. Sephton, Heather D. Durham


Lab

Journal
Neurotherapeutics

Abstract
Protein misfolding and mislocalization are common to both familial and sporadic forms of amyotrophic lateral sclerosis (ALS). Maintaining proteostasis

Keywords/Topics
Amyotrophic; lateral sclerosis;Heat shock ;proteins;FUSArimoclomol;Histone deacetylase inhibitor;Frontotemporal dementia

BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

Source :

https://www.sciencedirect.com/science/article/pii/S1878747924000746

Related products

Grip strength test

Publication request

Thank you for your interest in our product range and your request for this publication, which will be sent to you if the research team and the journal allow it. Our commercial team will contact you as soon as possible.