Spinal p38 MAPK and PGC-1alpha and SIRT3 signaling pathway mediates remifentanil-induced hyperalgesia in rats via ROS release and NR2B activation

Authors
Guoyan Feng, Fengxiang Song, Aiqi Wang, Lu Wang, Haotian Zhang, Shun Wang, Haitao Hou, Lianxiang Zhang, Liqin Deng


Lab

Journal
Neurochemistry International

Abstract
Remifentanil-induced hyperalgesia (RIH) poses a significant clinical challenge. Our research group has previously confirmed that abnormal activation o…

Keywords/Topics
pain;hyperalgesia

BIOSEB Instruments Used:
Electronic Von Frey - Wireless (BIO-EVF-WRS),Electronic Von Frey 5 with embedded camera (BIO-EVF5)

Source :

https://www.sciencedirect.com/science/article/pii/S0197018625001342

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