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TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sclerosis

06/01/2026 Amyotrophic Lateral Sclerosis (ALS) , Publications

Authors
Barone, Cassandra, Wang, Rihua, Cooke, Sarah, Ng, Hang Pong, Ferreira, Rodolfo S., Miranda, Helen C., Qi, Xin

Lab

Journal
Acta Neuropathologica

Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration and cytoplasmic mislocaliz

Keywords/Topics
Motor neuron; Metabolism; Glucose; Spinal cord

BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

Source :

https://link.springer.com/article/10.1007/s00401-026-02996-6

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