EEG and functional ultrasound imaging in mobile rats

Authors
Lim-Anna Sieu, Antoine Bergel, Elodie Tiran, Thomas Deffieux, Mathieu Pernot, Jean-Luc Gennisson, Mickaël Tanter & Ivan Cohen


Lab
Institut de Biologie Paris-Seine, INSERM U1130, CNRS UMR 8246, University Pierre et Marie Curie, Paris, France.

Journal
Nature Methods

Abstract
We developed an integrated experimental framework that extends the brain exploration capabilities of functional ultrasound imaging to awake and mobile rats. In addition to acquiring hemodynamic data, this method further allows parallel access to electroencephalography (EEG) recordings of neuronal activity. We illustrate this approach with two proofs of concept: a behavioral study on theta rhythm activation in a maze running task and a disease-related study on spontaneous epileptic seizures.

Source :

http://www.nature.com/nmeth/journal/v12/n9/full/nmeth.3506.html

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