Molecular and Functional Recovery in Contused Muscle Tissues Treated with Betulin in Mice

Authors
Dr. Maria S. Kovalenko, Dr. Elena I. Smirnova


Lab

Journal
International Research Journal of Medical Sciences and Health Care

Abstract
Muscle contusion injuries are common in trauma and sports medicine, often resulting in prolonged recovery and functional impairment. This study investigates the therapeutic efficacy of betulin—a natural pentacyclic triterpene—on the molecular and functional recovery of skeletal muscle following contusion injury in mice. Using a controlled murine injury model, betulin was administered post-injury, and recovery was evaluated through histological analysis, inflammatory marker profiling, and BIO-GS3ing. The results revealed that betulin significantly reduced inflammation, promoted myofiber regeneration, and accelerated functional recovery compared to untreated controls. Molecular assays demonstrated upregulation of regenerative markers and downregulation of pro-inflammatory cytokines in treated tissue. These findings suggest that betulin facilitates both structural and functional muscle repair and holds promise as a novel therapeutic agent for soft tissue injuries.

Keywords/Topics
Betulin; muscle regeneration; contusion injury; skeletal muscle; inflammation; functional recovery; tissue repair; natural compounds; mice model; triterpenes

BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

Source :

https://aimjournals.com/index.php/irjmshc/article/view/109

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