Prophylactic Effect of Echinacoside on Peripheral Neuropathy by Inhibiting Spinal Neuroinflammation and Exerting Neuroprotective Effects

Authors
Xue BAI, Chenghong SUN, Kai SONG, Xiaojun ZHOU, Li WANG, Xin LI, Qian ZHOU


Lab

Journal
Physiological Research

Abstract
Echinacoside (ECH), a naturally occurring phenylethanoid glycoside, has demonstrated promising therapeutic potential for neuropsychiatric disorders in preclinical studies [10]. Accumulating evidence indicates that ECH exerts multifaceted neuroprotective effects, including mitochondrial function preservation, oxidative stress reduction, anti-inflammatory activity, endoplasmic reticulum stress attenuation, and autophagy induction [11]. In the present study, we provide novel evidence that ECH (100 mg and 200 mg/kg, intraperitoneally) for 7 days effectively prevents the development of paclitaxel-induced peripheral neuropathy (PIPN) in mice. Our findings demonstrate that repeated ECH administration during PIPN induction significantly alleviated mechanical allodynia and thermal/cold hyperalgesia, suggesting a prophylactic role in neuropathic pain. The beneficial effects of ECH in PIPN were associated with the suppression of spinal microglial and astrocytic activation, along with reduced expression of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6). These findings align with previous reports on ECH’s anti-neuroinflammatory properties [12]. Furthermore, ECH treatment attenuated the loss of plantar nerve fibers, indicating its direct neuroprotective function. Given that neuroinflammation and peripheral nerve degeneration are key contributors to chemotherapy-induced neuropathy (CIPN) [13], our results suggest that ECH may act through multiple mechanisms to counteract PIPN pathogenesis.

Keywords/Topics
anti-inflammatory activity; mice; repeated ech administration; mechanical allodynia; thermal cold hyperalgesia; neuropathic pain; peripheral nerve degeneration; prophylactic effect; echinacoside; peripheral neuropathy

Source :

https://pmc.ncbi.nlm.nih.gov/articles/PMC13225448/

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