Bottlebrush polymer conjugates for enhanced antisense oligonucleotide therapy in myotonic dystrophy type 1

Authors
Li, Yao, Oetheimer, Christopher, Wang, Yuyan, Heo, Gyu Seong, Wu, Jiaqi, Chang, Rong, Zhang, Wei, Schneider, Elle, Chen, Junjie, Fang, Yang, Wei, Yun, Nian, Keqing, Zhang, Hengli, Sherman, Lauren, Liu, Yongjian, Zhang, Ke


Lab
pacDNA Inc.; Natick; MA 01760; United States; Department of Bioengineering; Northeastern University; Department of Biology; Northeastern University; College of Professional Studies; Northeastern University; Department of Chemical Engineering; Northeastern University; Copyright © 2026 Oxford University Press; University press partners; Oxford University Press; University of Oxford

Journal
Nucleic Acids Research

Abstract
Abstract. Oligonucleotides are a promising class of genetic medicine for myotonic dystrophy type 1 (DM1), the most common adult-onset muscular dystrophy. H

Keywords/Topics
hindlimb grip strength; bottlebrush polymer conjugates; enhanced antisense oligonucleotide therapy; myotonic dystrophy type; oligonucleotides; genetic medicine; h forelimb; bioseb; baseline

Source :

https://academic.oup.com/nar/article-abstract/54/12/gkag619/8715186

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