Microbiota-derived indole-3-propionic acid extends lifespan in Drosophila and improves muscle and bone health in mice

Authors
Vyavahare, Sagar, Berger, Ford, Swint, Shelton G., Mendhe, Bharati, Shukla, Mansi, Duchesne, Ian, Zhong, Roger, Cooley, Marion A., McGee-Lawrence, Meghan E., Isales, Carlos M., Hoffman, Jessica M., Fulzele, Sadanand


Lab

Journal
GeroScience

Abstract
Aging is associated with alterations in endogenous tryptophan (TRP) metabolism that contributes to musculoskeletal decline. In this study, we investigated

Keywords/Topics
Indole propionic acid; Aging; Senescence

Source :

https://link.springer.com/article/10.1007/s11357-025-02078-7

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