Site-targeted proximal complement C3 inhibition, but not C5 blockade, attenuates neurodegeneration in a mouse model of amyotrophic lateral sclerosis: Implications for failed clinical trials

Authors
Moumita Majumder, Davis M. Borucki, Nityananda Chowdhury, Khalil Mallah, Stephen Tomlinson


Lab

Journal
Neurotherapeutics

Abstract
Complement activation contributes to amyotrophic lateral sclerosis (ALS) neuropathology, but whether motor neuron degeneration is driven by proximal o

Keywords/Topics
neurodegeneration; motor neuron degeneration; not c5 blockade; amyotrophic lateral sclerosis; implications; failed clinical trials; complement activation; neuropathology; neuromuscular function; bioseb

Source :

https://www.sciencedirect.com/science/article/pii/S187874792600139X

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