GPRASP1 deletion suppresses antinociceptive tolerance during chronic activation of delta opioid receptor in persistent pain

Authors
Juliette Kaeffer, Marie-Laure Straub, Glenn-Marie Le Coz, Raphaëlle Quillet, Valérie Kugler, Nathalie Petit-Demoulière, Manon Gerum, Gabrielle Zeder-Lutz, Stéphane Doridot, Michael Dumas, Johana Chicher, Philippe Hammann, Philippe Marin, Franck Vandermoere, Dominique Massotte, Frédéric Simonin, Sandra Lecat


Lab

Journal
Biomedicine & Pharmacotherapy

Abstract
Delta-opioid receptor (DOR) agonists display antinociceptive properties with less adverse effects than morphine derivatives and other opioids targetin

Keywords/Topics
persistent pain delta-opioid receptor; gprasp1 deletion; antinociceptive tolerance; chronic activation; delta; opioid receptor; agonists; antinociceptive properties; less adverse effects; morphine derivatives

Source :

https://www.sciencedirect.com/science/article/pii/S0753332225011072

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