Impact of chronic opioid on cognitive function and spermatogenesis in rat- An experimental study

Authors
Hamid Norioun, Seyed Jamal Moshtaghian, Firoozeh Alavian, Maryam Khombi Shooshtari, Golnaz Alipour, Saeedeh Ghiasvand


Lab

Journal
International Journal of Reproductive Biomedicine

Abstract
Methadone and morphine, commonly prescribed narcotics for pain management, exert their effects by inhibiting pain signal transmission through the spinothalamic tract and activating pain control mechanisms in higher nerve centers (1). These opioids can impact memory, anxiety, and cognitive function, particularly with chronic usage and at high doses, leading to tolerance, dependence, and alterations in brain function (2). Reproductive system dysfunction, including decreased serum testosterone levels in men, has been reported in chronic users of methadone and morphine (3, 4). Long-term opioid use can disrupt neurotransmitter systems and neuroplasticity, affecting memory formation and cognitive function, while also posing a risk of overdose and potential neurological damage (5). Furthermore, prolonged morphine use may influence genes involved in sperm production, such as the tumor protein p53 (Tp53orp53), which plays a crucial role in spermatogenesis and male fertility (6). Dysregulation ofTp53can lead to impaired sperm production and quality, increasing the risk of testicular germ cell tumors and male infertility (7). Similarly, dysregulation or mutations in the sperm-associated cation channel 1 (CatSper1) can disrupt calcium signaling, impair sperm motility, and reduce fertilization potential, contributing to male infertility (8, 9). This study aimed to elucidate the long-term effects of methadone and morphine administration, highlighting the physiological consequences and underlying mechanisms associated with chronic opioid use.

Keywords/Topics
Rat ; Spermatogenesis ; CatSper1 ; Tp53 ; Morphine ; Methadone ; Cognition

BIOSEB Instruments Used:
Rodent pincher - Analgesia meter - Wireless (BIO-RP-WRS)

Source :

https://pmc.ncbi.nlm.nih.gov/articles/PMC11441285/

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