PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect

Authors
Venot, Quitterie, Firpion, Marina, Ladraa, Sophia, Bayard, Charles, Magassa, Sato, Di Guardo, Roberta, Fraissenon, Antoine, Hoguin, Clément, Protic, Sanela, Morin, Gabriel, Mayeux, Franck, Gourdon, Genevieve, Fraitag, Sylvie, Balducci, Estelle, Kaltenbach, Sophie, Villarese, Patrick, Asnafi, Vahid, Viel, Thomas, Autret, Gwennhael, Tavitian, Bertrand, Goudin, Nicolas, Guibaud, Laurent, Bolino, Alessandra, Canaud, Guillaume


Lab

Journal
Proceedings of the National Academy of Sciences

Abstract
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Keywords/Topics
somatic mutation; nerve anomalies; PIK3CA

BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

Source :

https://www.pnas.org/doi/abs/10.1073/pnas.2424867122

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