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Latest publication 12/19/2025

Exosomes derived from platelet-rich plasma alleviate synovial inflammation by en

Synovial inflammation is a pivotal factor in the pathogenesis of osteoarthritis (OA). Platelet-rich plasma-derived Exosomes (PRP-Exos), known for...

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    [title] => Exosomes derived from platelet-rich plasma alleviate synovial inflammation by en
    [paragraph] => Exosomes derived from platelet-rich plasma alleviate synovial inflammation by enhancing synovial lymphatic function
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Authors
Liao, Bo, Tian, Yu, Guan, Mengtong, Han, Wang, Yi, Weiwei, Li, Kaiting, Yang, Xiaoliang, Niu, Yajuan, Zhang, Bin, Teng, Peiyu, Bai, Dingqun, Kuang, Liang, Zhu, Ying, Han, Xiaoyu

 Lab

Journal
Journal of Nanobiotechnology
Abstract
Synovial inflammation is a pivotal factor in the pathogenesis of osteoarthritis (OA). Platelet-rich plasma-derived Exosomes (PRP-Exos), known for their low immunogenicity, have demonstrated efficacy in modulating chondrocyte function. However, the specific effects and mechanisms of PRP-Exos in synovial inflammation remain unclear. This study aimed to investigate the therapeutic effects and mechanisms of PRP-Exos in synovial inflammation induced by destabilization of the medial meniscus (DMM) in mice. PRP-Exos were extracted via ultracentrifugation. In vivo experiments revealed that PRP-Exos alleviated pain behaviors and synovial inflammation in DMM mice. Furthermore, it was discovered that PRP-Exos enhanced the synovial lymphatic function in DMM mice and promoted lymphangiogenesis. Meanwhile, the therapeutic effect of PRP-Exos on synovial inflammation was attenuated after inhibition of lymphatic function. In vitro studies demonstrated that PRP-Exos enhanced the proliferation, migration, and tube formation ability of lymphatic endothelial cells (LECs), via regulating the PI3K/Akt signaling pathway. Conclusions: This research is the first to reveal that PRP-Exos alleviate pain behaviors and synovial inflammation in DMM mice through activation of the PI3K/Akt signaling pathway in LECs, thereby enhancing synovial lymphatic function and promoting the clearance of inflammatory cells and associated cytokines. These findings offer a novel theoretical foundation for the treatment of synovial inflammation and other inflammation-associated disorders.
Keywords/Topics
Platelet-rich plasma-derived exosome; Synovial inflammation; Lymphatic vessel
BIOSEB Instruments Used:
Electronic Von Frey - Wireless (BIO-EVF-WRS),Electronic Von Frey 5 with embedded camera (BIO-EVF5),Static Weight Bearing Touch: Incapacitance Test (BIO-SWB-TOUCH-M)
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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An easy and non pain-inducing solution for assessing the level of discomfort (incapacitance) in the injured paw of a small animal like a rat or a mouse by measuring the Postural Equilibrium “ independently of the operator". The static weight bearing instrument is ideal for your research on analagesia and nociception involving rodents: osteo arthrisis, cartilage degeneration, inflammation models, nerve injury models, and much more... Discover the SWB-Touch: now with a brand new touch-screen console!

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