Bleomycin triggers chronic mechanical nociception by activating TRPV1 and glial reaction-mediated neuroinflammation via TSLP and TSLPR and pSTAT5 signals

Authors
Ying-Yi Lu, Chia-Yang Lin, Chun-Ching Lu, Hung-Pei Tsai, Wei-Ting Wang, Zi-Hao Zhang, Chieh-Hsin Wu


Lab

Journal
Brain Research Bulletin

Abstract
Chronic pain is a universal public health problem with nearly one third of global human involved, which causes significant distressing personal burden

Keywords/Topics
Bleomycin;Chronic pain;Glial cells;NeuronsTSLPTRPV1

BIOSEB Instruments Used:
Rodent pincher - Analgesia meter - Wireless (BIO-RP-WRS)

Source :

https://www.sciencedirect.com/science/article/pii/S0361923024002156

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