Altered IRF1–miR-20a-5p regulatory axis in the hippocampus of patients with major depressive disorder

Authors
Mariko Okano, Yuta Yoshino, Anuj K. Verma, Hiroshi Kumon, Hiroaki Mori, Motoyasu Hosokawa, Jun-ichi Iga, Yogesh Dwivedi, Akihide Takeuchi, Shu-ichi Ueno


Lab

Journal
Psychiatry and Clinical Neurosciences

Abstract
Figure S2.Effect of confounding variables on the expression of miR-20a-5p. There were no significant correlations between miR-20a-5p expression and age (r = 0.10,P= 0.59) (A), and PMI (r = 0.22,P= 0.27) (B), brain pH (r = 0.09,P= 0.66) (C). The expression level of miR-20a-5p was not significantly different (df = 12, F = 0.59,P= 0.10) between MDD subjects who had positive antidepressant (AD) toxicology and those who did not (D). Also, there was no significant difference in the expression of IRF1 between males and females (df = 12, F = 0.75,P= 0.69) (E). Each bar plot presents data in the mean ± SEM.

Keywords/Topics
hippocampus; IRF1; major depressive disorder; microRNA; neuroinflammation

Source :

https://onlinelibrary.wiley.com/doi/abs/10.1111/pcn.70111

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