Publications

Latest publication 11/25/2013

T-type channel blockade impairs long-term potentiation at the parallel fiber-Pur

CaV3.1 T-type channels are abundant at the cerebellar synapse between parallel fibers and Purkinje cells where they contribute to synaptic...

Array
(
    [id_prestablog_news] => 620
    [id_shop] => 1
    [date] => 2013-11-25 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 1213
    [id_lang] => 1
    [title] => T-type channel blockade impairs long-term potentiation at the parallel fiber-Pur
    [paragraph] => T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning
    [content] => 
Authors
R. Ly, G. Bouvier, M. Schonewille, A. Arabo, L. Rondi-Reig et al.

 Lab
Institut de Biologie de l'Ecole Normale Supérieure, Paris, France.
Journal
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Abstract
CaV3.1 T-type channels are abundant at the cerebellar synapse between parallel fibers and Purkinje cells where they contribute to synaptic depolarization. So far, no specific physiological function has been attributed to these channels neither as charge carriers nor more specifically as Ca(2+) carriers. Here we analyze their incidence on synaptic plasticity, motor behavior, and cerebellar motor learning, comparing WT animals and mice where T-type channel function has been abolished either by gene deletion or by acute pharmacological blockade. At the cellular level, we show that CaV3.1 channels are required for long-term potentiation at parallel fiber-Purkinje cell synapses. Moreover, basal simple spike discharge of the Purkinje cell in KO mice is modified. Acute or chronic T-type current blockade results in impaired motor performance in particular when a good body balance is required. Because motor behavior integrates reflexes and past memories of learned behavior, this suggests impaired learning. Indeed, subjecting the KO mice to a vestibulo-ocular reflex phase reversal test reveals impaired cerebellum-dependent motor learning. These data identify a role of low-voltage activated calcium channels in synaptic plasticity and establish a role for CaV3.1 channels in cerebellar learning. 
BIOSEB Instruments Used
Aron Test or Four Plates Test (LE830),Rotarod (BX-ROD)
    [meta_description] => 
    [meta_keywords] => http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864350/
    [meta_title] => 
    [link_rewrite] => t-type-channel-blockade-impairs-long-term-potentiation-at-the-parallel-fiber-purkinje-cell-synapse-and-cerebellar-learning
    [actif_langue] => 1
    [read] => 1422
    [count_comments] => 0
    [id] => 620
    [categories] => Array
        (
            [78] => Array
                (
                    [id_prestablog_categorie] => 78
                    [title] => Cell metabolism
                    [link_rewrite] => Cell-metabolism
                )

            [23] => Array
                (
                    [id_prestablog_categorie] => 23
                    [title] => Metabolism
                    [link_rewrite] => Metabolism
                )

            [14] => Array
                (
                    [id_prestablog_categorie] => 14
                    [title] => Motor control
                    [link_rewrite] => Motor-control
                )

            [54] => Array
                (
                    [id_prestablog_categorie] => 54
                    [title] => Motor Deficits
                    [link_rewrite] => Motor-Deficits
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [588] => Array
                (
                    [name] => Aron Test or Four Plates Test
                    [description_short] => 
The Four Plates Test is an exclusivity from BIOSEB!
The Aron test allows a quick characterization of putative anxiolytics compounds in naïve animals. A must for studying anxiety, drug screening and phenotyping.
                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/anxiety-depression-disorder/588-aron-test-or-four-plates-test.html
                )

            [1326] => Array
                (
                    [name] => Rotarod for rats and mice
                    [description_short] => 
Rotarod provides an easy way to test the motor activity in rodents (mouse or rat) - an ideal solution for studying central nervous system damage, disease effects on motor activity, drugs administration, fatigue resistance, etc. Now even easier to use! The new touchscreen graphic user interface allows clear visualization of timing and speed for each lane. Change modes, adjust speed, and create protocols right from the main screen for greater flexibility with maximum functionality and usability

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/activity-motor-control-coordination/1326-rotarod.html
                )

        )

)
1