Publications

Latest publication 11/06/2016

Antiresorptive and Anabolic Bone Therapy Does not Improve Weight Bearing Capacit

Osteoarthritis (OA) is a leading cause of disability, but despite the high unmet clinical need and extensive research seeking dependable...

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    [title] => Antiresorptive and Anabolic Bone Therapy Does not Improve Weight Bearing Capacit
    [paragraph] => Antiresorptive and Anabolic Bone Therapy Does not Improve Weight Bearing Capacity and Bone Strength in OA Rats
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Authors
Cedo M. Bagi,corresponding author Edwin Berryman, David E. Zakur, Dean Wilkie, and Catharine J. Andresen

 Lab
Comparative Medicine, Global Science and Technology, Pfizer Global Research and Development, Pfizer Inc., 100 Eastern Point Road, Groton, CT 06340 USA
Journal
Arthritis Res Ther. 
Abstract
Osteoarthritis (OA) is a leading cause of disability, but despite the high unmet clinical need and extensive research seeking dependable therapeutic interventions, no proven disease-modifying treatment for OA is currently available. Due to the close interaction and interplay between the articular cartilage and the subchondral bone plate, it has been hypothesized that antiresorptive drugs can also reduce cartilage degradation, inhibit excessive turnover of the subchondral bone plate, prevent osteophyte formation, and/or that bone anabolic drugs might also stimulate cartilage synthesis by chondrocytes and preserve cartilage integrity. The benefit of intensive zoledronate (Zol) and parathyroid hormone (PTH) therapy for bone and cartilage metabolism was evaluated in a rat model of OA.
BIOSEB Instruments Used
Static Weight Bearing Touch: Incapacitance Test (BIO-SWB-TOUCH-M)
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An easy and non pain-inducing solution for assessing the level of discomfort (incapacitance) in the injured paw of a small animal like a rat or a mouse by measuring the Postural Equilibrium “ independently of the operator". The static weight bearing instrument is ideal for your research on analagesia and nociception involving rodents: osteo arthrisis, cartilage degeneration, inflammation models, nerve injury models, and much more... Discover the SWB-Touch: now with a brand new touch-screen console!

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