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Latest publication 09/01/2017

Primeras fases del desarrollo de un modelo experimental para el estudio de la re

Aim: To develop an animal model of chronic rotator cuff tear. To induce a chronic pattern similar to human being. Methods: A randomized with 40...

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    [title] => Primeras fases del desarrollo de un modelo experimental para el estudio de la re
    [paragraph] => Primeras fases del desarrollo de un modelo experimental para el estudio de la reparación de las roturas del manguito rotador
    [content] => 
Authors
G. Busto, A. Jauregui, R. Cuellar

 Lab
Instituto de Investigación Sanitaria Biodonostia. Donostia-San Sebastián, Gipuzkoa
Journal
ARTROSCOPIA Y CIRUGÍA ARTICULAR
Abstract
Aim:
To develop an animal model of chronic rotator cuff tear. To induce a chronic pattern similar to human being. 
Methods: 
 A randomized with 40 Wistar-Ham rats 200300 grams. Both forelimbs in 2 groups were involved: a) simple technique of tendon detachment (ST); b) technique in which suprascapular nerve denervation (DT) was added. At 4, 8 and 12 weeks were made macro- and microscopic study. The contralateral side served as control. 
 Results: 
 Both the TS and TD weight and volume produced supraspinatus (SE) and infraspinatus (IE) below the shoulder control. This effect was maintained over time. Muscle fatty infiltration increased over time and was higher at 12 weeks by TD in the muscles SE (p < 0.004) and IE (p < 0.02) than in controls. We found no significant differences in tendon parameters. 
Conclusions: 
 The changes in muscle histological properties were those of a chronic rotator cuff tear model reproducible and maintained over time. The effect of denervation in the group with the DT technique produced greater muscle fatty infiltration maintained over time highest ranking in the SE. We found no significant differences in the studied parameters tendon and was indifferent perform a technique or another as long as it was complete section of 2 or more rotator cuff tendons.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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