Publications

Latest publication 12/01/2020

The adjuvant-induced rat model of monoarthritis- welfare implications and possib

This study investigated welfare, mechanical hyperalgesia and model specific parameters (mobility, stance, joint stiffness and ambulation...

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    [title] => The adjuvant-induced rat model of monoarthritis- welfare implications and possib
    [paragraph] => The adjuvant-induced rat model of monoarthritis: welfare implications and possible refinement strategies
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Authors
MS Berke, KSP Abelson 

 Lab
Department of Experimental Medicine, Copenhagen N, Denmark
Journal
Scandinavian Journal of Laboratory Animal Science
Abstract
This study investigated welfare, mechanical hyperalgesia and model specific parameters (mobility, stance, joint stiffness and ambulation impairment) during a three-week period in a rat model of monoarthritis. The objective was to identify possible targets for refinement of the model and consequently improve animal welfare. Monoarthritis was induced in eight male Sprague-Dawley rats by an intra-articular injection of 20 microL Complete Freund
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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