Lower back & discs Scientific Publications

Latest publication 06/16/2022

Sex-Related Pain Behavioral Differences following Unilateral NGF Injections in a

Low back pain (LBP) is a globally prevalent and costly societal problem with multifactorial etiologies and incompletely understood...

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    [date] => 2022-06-16 00:00:00
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    [title] => Sex-Related Pain Behavioral Differences following Unilateral NGF Injections in a
    [paragraph] => Sex-Related Pain Behavioral Differences following Unilateral NGF Injections in a Rat Model of Low Back Pain
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Authors
M Syrett, NR Reed, WR Reed

 Lab
Saint Louis University School of Medicine, Saint Louis, MO
Journal
Biology
Abstract
Low back pain (LBP) is a globally prevalent and costly societal problem with multifactorial etiologies and incompletely understood pathophysiological mechanisms. To address such shortcomings regarding the role of neurotrophins in the underlying mechanisms of pain, an LBP model was developed in rats involving two unilateral intramuscular injections of nerve growth factor (NGF) into deep trunk muscles. To date, behavioral investigations of this NGF-LBP model have been limited, especially as it pertains to female pain behaviors. This study compared mechanical sensitivity to noxious (hyperalgesia) and non-noxious (hypersensitivity) stimuli in control and NGF-injected male and female rats through pain resolution. Although the baseline testing revealed no differences between males and females, NGF-injected females demonstrated prolonged ipsilateral deep trunk mechanical hyperalgesia that resolved seven days later than males. Moreover, females showed bilateral trunk mechanical sensitivity to noxious and non-noxious stimuli compared to only ipsilateral behaviors in males. Sex differences were also observed in the severity of behavioral responses, with females displaying greater mean differences from baseline at several timepoints. Overall, these NGF-LBP behavioral findings mirror some of the sex differences reported in the clinical presentation of LBP and accentuate the translatability of this NGF-LBP model. Future studies using this LBP-NGF model could help to elucidate the neurobiological mechanisms responsible for the development, severity, and/or resolution of muscular LBP as well as to provide insights into the processes governing the transition from acute to chronic LBP.
BIOSEB Instruments Used
SMALGO: SMall animal ALGOmeter (BIO-SMALGO)
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Dedicated to small animals, like mice and rats, Smalgo is a pressure-based analgesimeter designed for easy assessment of sensitivity threshold. It is a must for osteo-arthritis and pain studies. A quick, easy-to-use and reliable instrument to assess threshold sensitivity of the animal when applying a progressive force, which can also be used for drug screening, phenotyping, as well as on studies about neuropathy, inflammation and post-operative pain. Now wireless, to be free from annoying cables!

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