Bone mass Scientific Publications

Latest publication 04/04/2018

FAM210A is a novel determinant of bone and muscle structure and strength

Osteoporosis and sarcopenia are common comorbid diseases, yet their shared mechanisms are largely unknown. We found that genetic variation near...

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    [title] => FAM210A is a novel determinant of bone and muscle structure and strength
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Authors
K Tanaka, Y Xue, L Nguyen-Yamamoto, JA Morris, I Kanazawa, T Sugimoto, SS Wing, JB Richards, D Goltzman

 Lab
McGill University, Montreal, QC, Canada
Journal
PNAS
Abstract
Osteoporosis and sarcopenia are common comorbid diseases, yet their shared mechanisms are largely unknown. We found that genetic variation near FAM210A was associated, through large genome-wide association studies, with fracture, bone mineral density (BMD), and appendicular and whole body lean mass, in humans. In mice, Fam210a was expressed in muscle mitochondria and cytoplasm, as well as in heart and brain, but not in bone. Grip strength and limb lean mass were reduced in tamoxifen-inducible Fam210a homozygous global knockout mice (TFam210a_/_), and in tamoxifen-inducible Fam210 skeletal muscle cell-specific knockout mice (TFam210aMus_/_). Decreased BMD, bone biomechanical strength, and bone formation, and elevated osteoclast activity with microarchitectural deterioration of trabecular and cortical bones, were observed in TFam210a_/_ mice. BMD of male TFam210aMus_/_ mice was also reduced, and osteoclast numbers and surface in TFam210aMus_/_ mice increased. Microarray analysis of muscle cells from TFam210aMus_/_ mice identified candidate musculoskeletal modulators. FAM210A, a novel gene, therefore has a crucial role in regulating bone structure and function, and may impact osteoporosis through a biological pathway involving muscle as well as through other mechanisms.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Muscular atrophy; Bone mass; Muscular system; Skeletal system
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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