Publications

Latest publication 04/30/2007

Behavioral and pharmacological description of oxaliplatin-induced painful neurop

We describe an animal model of nociceptive sensory neuropathy induced by repeat intravenous administration of oxaliplatin in which treated animals...

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    [title] => Behavioral and pharmacological description of oxaliplatin-induced painful neurop
    [paragraph] => Behavioral and pharmacological description of oxaliplatin-induced painful neuropathy in rat.
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Authors
B. Ling, N. Authier, D. Balayssac, A. Eschalier, F. Coudore.

 Lab
Université Clermont1, Faculté de Pharmacie, Laboratoire de Toxicologie, Clermont-Ferrand, France.
Journal
Pain
Abstract
We describe an animal model of nociceptive sensory neuropathy induced by repeat intravenous administration of oxaliplatin in which treated animals partly reproduce the characteristic pain symptoms in oxaliplatin-treated patients. We tested the ability of 1, 2 and 4 mg/kg oxaliplatin doses injected twice-weekly for four-and-a-half consecutive weeks to induce a nociceptive peripheral neuropathy in male Sprague–Dawley rats. The behavioral assessment revealed cold allodynia (10 °C) and hyperalgesia (4 °C) symptoms associated with a mechanical allodynia. The rats maintained a good general clinical status without motor dysfunction. The 2 mg/kg oxaliplatin dose and the tail-immersion test in cold water (10 °C) were selected to compare pharmacological sensitivity between single administered drugs as morphine, lidocaine, carbamazepine, gabapentin and repeated administration of drugs as clomipramine, venlafaxine, calcium and magnesium solutions. Magnesium solution (90 mg/kg) and venlafaxine (7.5 mg/kg) administration induced an antinociceptive effect whereas gabapentin (300 mg/kg), clomipramine (2.5 mg/kg) and lidocaine (3 and 6 mg/kg) only induced an antiallodynic effect.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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