Publications

Latest publication 04/30/2004

Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in th

The objective of this study was to resolve discrepancies regarding the possible antinociceptive synergy between morphine and nefopam in animal...

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    [title] => Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in th
    [paragraph] => Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in the rat.
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Authors
P. Girard, Y. Pansart, J.-M. Gillardin.

 Lab
Laboratoires Biocodex, Service de Pharmacologie, Compiègne, France.
Journal
Pharmacology Biochemistry and Behavior
Abstract
The objective of this study was to resolve discrepancies regarding the possible antinociceptive synergy between morphine and nefopam in animal models of pain. Firstly, we have examined the antinociceptive activity of nefopam, a nonopioid antinociceptive compound that inhibits monoamine reuptake, in pain models of allodynia and hyperalgesia induced by carrageenan injection, or skin and muscle incision of the rat hind paw. Single subcutaneous administration of nefopam at 30 mg/kg blocked carrageenan- and incision-induced thermal hyperalgesia, and weakly but significantly diminished carrageenan-induced tactile allodynia. A weaker dose of nefopam (10 mg/kg) only reduced carrageenan-induced tactile allodynia and incision-induced thermal hyperalgesia. Secondly, we assessed the usefulness of the coadministration of nefopam with morphine. Combination of a nonanalgesic dose of nefopam (10 mg/kg) with a nonanalgesic dose of morphine (0.3 or 1.0 mg/kg) completely inhibited carrageenan- or incision-induced thermal hyperalgesia, respectively. In carrageenan-induced tactile allodynia, coadministration of weak analgesic doses of nefopam (10 and 30 mg/kg) with a nonanalgesic dose (1 mg/kg) or moderately analgesic dose (3 mg/kg) of morphine significantly reduced or reversed allodynia, respectively. In conclusion, coadministration of nefopam with morphine enhances the analgesic potency of morphine, indicating a morphine sparing effect of nefopam.
BIOSEB Instruments Used
SMALGO: SMall animal ALGOmeter (BIO-SMALGO)
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Dedicated to small animals, like mice and rats, Smalgo is a pressure-based analgesimeter designed for easy assessment of sensitivity threshold. It is a must for osteo-arthritis and pain studies. A quick, easy-to-use and reliable instrument to assess threshold sensitivity of the animal when applying a progressive force, which can also be used for drug screening, phenotyping, as well as on studies about neuropathy, inflammation and post-operative pain. Now wireless, to be free from annoying cables!

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