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Latest publication 02/01/2011

Longitudinal study of wind-up responses after graded spinal cord injuries in the

PURPOSE: The main objectives of this work were to evaluate the development of neuropathic pain after spinal cord injuries of different severities,...

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    [date] => 2011-02-01 00:00:00
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    [title] => Longitudinal study of wind-up responses after graded spinal cord injuries in the
    [paragraph] => Longitudinal study of wind-up responses after graded spinal cord injuries in the adult rat. 
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Authors
E. Redondo Castro, E. Udina, E. Verdú, X. Navarro. 

 Lab
 Institute of Neurosciences and Department of Cell Biology, Group of Neuroplasticity and Regeneration, Bellaterra, Spain.
Journal
Restorative neurology and Neuroscience
Abstract
PURPOSE: The main objectives of this work were to evaluate the development of neuropathic pain after spinal cord injuries of different severities, and to assess changes in central excitability and plasticity by means of wind-up responses and withdrawal reflexes. METHODS: Two groups of rats were subjected to spinal cord contusion with forces of 100 or 200 kdyn applied at T8. Measurements of thermal and mechanical pain thresholds as well as wind-up measurements were performed weekly during two months after injury. Withdrawal reflexes were also assessed electrophysiologically. RESULTS: We found that animals with contusion of different severities showed a similar reduction in nociceptive thresholds. All contused animals showed increased wind-up responses compared to intact animals during the first 2 to 6 weeks post injury. The mean increase of wind-up was higher in rats with stronger spinal cord contusion. Results from the withdrawal reflexes did not correlate with nociceptive behaviors nor wind-up responses, highlighting the plasticity of spinal circuits modulation after SCI. CONCLUSION: These results indicate that the graded-force spinal cord contusion model is suitable for studying central neuropathic pain, and for assessing changes in wind-up responses. Wind-up measurements can be used as a non-invasive technique to detect changes in central excitability after SCI of different severities.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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