Publications

Latest publication 06/29/2018

Anti-inflammatory effects of Metformin improve the neuropathic pain and locomoto

Metformin is a safe drug for controlling blood sugar in diabetes. It has been shown that metformin improves locomotor recovery after spinal cord...

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    [title] => Anti-inflammatory effects of Metformin improve the neuropathic pain and locomoto
    [paragraph] => Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy
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Authors
K Afshari, A Dehdashtian, N-S Haddadi, A Haj-Mirzaian, A Iranmehr, M Ali Ebrahimi, SM Tavangar, H Faghir-Ghanesefat, F Mohammadi, N Rahimi, AN Javidan, A R Dehpou

 Lab
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
Journal
Spinal Chord
Abstract
Metformin is a safe drug for controlling blood sugar in diabetes. It has been shown that metformin improves locomotor recovery after spinal cord injury (SCI). Neuropathic pain is also a disturbing component of SCI. It is indicated that metformin has neuroprotective and anti-inflammatory effects, which attenuate neuropathic pain and hyperalgesia in injured nerves. Thus, we evaluated metformin’s therapeutic effects on SCI neuroinflammation and its sensory and locomotor complications. Meanwhile, results were compared to minocycline, an anti-neuroinflammation therapy in SCI.
BIOSEB Instruments Used
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