Cardiac function - page 2 Scientific Publications

Latest publication 10/30/2018

May a sigma_1 antagonist improve neuropathic signs induced by cisplatin and vinc

Rats treated with antitumourals developed tactile allodynia, while those treated with vincristine also developed mechanical hyperalgesia. These in...

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    [title] => May a sigma_1 antagonist improve neuropathic signs induced by cisplatin and vinc
    [paragraph] => May a sigma_1 antagonist improve neuropathic signs induced by cisplatin and vincristine in rats?
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Authors
N Paniagua, C Goicoechea, R Abalo

 Lab
Universidad Rey Juan Carlos, Alcorcón, Spain.
Journal
European Journal of Pain
Abstract
Rats treated with antitumourals developed tactile allodynia, while those treated with vincristine also developed mechanical hyperalgesia. These in vivo modifications correlated with electrophysiological hyperactivity (increased spontaneous activity and hyperresponsiveness to innocuous and noxious mechanical stimulation). Animals treated with cisplatin showed gastrointestinal impairment and those receiving vincristine showed cardiovascular toxicity. A single dose of MR_309 strongly reduced both nociceptive behaviour and electrophysiological changes. Moreover, its concomitant administration with the antitumourals blocked the development of neuropathic symptoms, thus restoring mechanical sensitivity, improving the impairment of feeding behaviour and gastrointestinal transit in the cisplatin_treated group along with ameliorating the altered vascular reactivity recorded in rats treated with vincristine.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying cables!

This precise and easy-to-use electronic instrument is a must-have reference for your research in analgesia, nociception, neuro-pathologies and post-operative pain.

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The EVF5 includes an embedded camera inside the stimulator handle and a new, dedicated software revolutionizing the experimental process.

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